[Severe psychosis in an African woman due to the antiretroviral agent efavirenz].
Identifieur interne : 000E54 ( Main/Exploration ); précédent : 000E53; suivant : 000E55[Severe psychosis in an African woman due to the antiretroviral agent efavirenz].
Auteurs : G. Van Twillert [Pays-Bas] ; G. Van Santen ; M H GodfriedSource :
- Nederlands tijdschrift voor geneeskunde [ 0028-2162 ] ; 2005.
Descripteurs français
- KwdFr :
- Adulte, Agents antiVIH (effets indésirables), Agents antiVIH (pharmacocinétique), Agents antiVIH (usage thérapeutique), Benzoxazines, Clairance métabolique (génétique), Femelle, Ghana (ethnologie), Humains, Infections à VIH (traitement médicamenteux), Oxazines (effets indésirables), Oxazines (pharmacocinétique), Oxazines (usage thérapeutique), Pays-Bas, Population d'origine africaine (génétique), Troubles psychotiques (ethnologie), Troubles psychotiques (étiologie).
- MESH :
- effets indésirables : Agents antiVIH, Oxazines.
- ethnologie : Ghana, Troubles psychotiques.
- génétique : Clairance métabolique, Population d'origine africaine.
- pharmacocinétique : Agents antiVIH, Oxazines.
- traitement médicamenteux : Infections à VIH.
- usage thérapeutique : Agents antiVIH, Oxazines.
- étiologie : Troubles psychotiques.
- Adulte, Benzoxazines, Femelle, Humains, Pays-Bas.
- Wicri :
- geographic : Ghana.
English descriptors
- KwdEn :
- Adult, African Continental Ancestry Group (genetics), Anti-HIV Agents (adverse effects), Anti-HIV Agents (pharmacokinetics), Anti-HIV Agents (therapeutic use), Benzoxazines, Female, Ghana (ethnology), HIV Infections (drug therapy), Humans, Metabolic Clearance Rate (genetics), Netherlands, Oxazines (adverse effects), Oxazines (pharmacokinetics), Oxazines (therapeutic use), Psychotic Disorders (ethnology), Psychotic Disorders (etiology).
- MESH :
- chemical , adverse effects : Anti-HIV Agents, Oxazines.
- geographic , ethnology : Ghana.
- drug therapy : HIV Infections.
- ethnology : Psychotic Disorders.
- etiology : Psychotic Disorders.
- genetics : African Continental Ancestry Group, Metabolic Clearance Rate.
- chemical , pharmacokinetics : Anti-HIV Agents, Oxazines.
- chemical , therapeutic use : Anti-HIV Agents, Oxazines.
- Adult, Benzoxazines, Female, Humans, Netherlands.
Abstract
A 34-year-old woman originally from Ghana was given efavirenz as antiretroviral therapy. One week later she was found to be in a psychotic state with paranoid hallucinations and anxiety; she then stabbed a nurse. The literature indicates that female patients of African origin appear to be more susceptible to the side effects of efavirenz due to genetically reduced clearance and therefore higher serum levels.
PubMed: 16358620
Affiliations:
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Le document en format XML
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Van Twillert</name><affiliation wicri:level="1"><nlm:affiliation>Academisch Medisch Centrum/Universiteit van Amsterdam, afd. Inwendige Geneeskunde, Meibergdreefg, 1105 AZ Amsterdam. g.vantwillert@amc.uva.nl</nlm:affiliation><country wicri:rule="url">Pays-Bas</country></affiliation></author><author><name sortKey="Van Santen, G" sort="Van Santen, G" uniqKey="Van Santen G" first="G" last="Van Santen">G. 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One week later she was found to be in a psychotic state with paranoid hallucinations and anxiety; she then stabbed a nurse. The literature indicates that female patients of African origin appear to be more susceptible to the side effects of efavirenz due to genetically reduced clearance and therefore higher serum levels.</div></front></TEI><affiliations><list><country><li>Pays-Bas</li></country></list><tree><noCountry><name sortKey="Godfried, M H" sort="Godfried, M H" uniqKey="Godfried M" first="M H" last="Godfried">M H Godfried</name><name sortKey="Van Santen, G" sort="Van Santen, G" uniqKey="Van Santen G" first="G" last="Van Santen">G. Van Santen</name></noCountry><country name="Pays-Bas"><noRegion><name sortKey="Van Twillert, G" sort="Van Twillert, G" uniqKey="Van Twillert G" first="G" last="Van Twillert">G. Van Twillert</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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